A Redox Stress Test has been developed to identify symptoms of diseases driven by oxidative stress. Symptom changes induced by short-term activation of the transcription factor Nrf2, point to redox homeostasis being restored in the organs concerned. The Nrf2 pathway is triggered by a formulation developed to deliver highly bioavailable sulforaphane, a potent activator of Nrf2. The Redox Stress Test has demonstrated remarkable and simultaneous alleviation of a wide range of Parkinson’s non-motor symptoms, such as fatigue, constipation, and urinary urgency, while leaving motor symptoms entirely unaffected. This compelling observation suggests that oxidative stress could be a common underlying factor contributing to non-motor symptoms in both peripheral organs and the brain. The findings are interpreted within the framework of a hypothetical model for Parkinson’s Syndrome as a multi-system redox disorder, with pockets of the disease present in peripheral organs as well as the brain. Eliminating the disease in peripheral organs is therefore essential to halt the progression of the disease in the brain.

Article published in Medical Research Archives Vol. 12, N° 1, January (2024), 4955.