The Broccoli & Sulforaphane Research Group for Parkinson’s Disease

Page 3: Contents

Page 3: Frequently-asked questions

Q: Where can I get the high quality broccoli seeds?

BS-RG has been fortunate to obtain a significant stock of broccoli seeds with a very high, quantified glucoraphanin content. These high-quality seeds are strictly reserved for the Group’s research activities. They will be used as the main standardized source material for all experiments and comparative tests for the coming months.  BS-RG is not authorized to sell these seeds to any third party nor to disclose the supplier, their origin or any other details. These seeds are not available for sale to the general public. BS-RG does not currently have reliable information on the glucoraphanin content of other commercially available broccoli seeds. Part of the research program will be to identify commercial sources of high-quality broccoli seeds and to analyse them for their glucoraphanin content so that members can use such seeds for their own experiments if they so choose.

Q: My parkinson’s disease is progressing rapidly, how do I get access to the seeds and protocol?

We fully understand that some people may wish to join the group mainly gain access to high-quality seeds and the processing protocol to test whether BST might attenuate their own Parkinson’s disease symptoms. We fully sympathise with this reasoning. However, the BS-RG has neither the structure, the capacity nor the seed quantities to respond to that need.

Having said that, the overall objective of the research program we propose is intended to provide new information to enable BS-RG members to satisfy that need for themselves.

​Q: How can I participate in self-experimentation?

​The BS-RG research program is focused on evaluating the impact of activating the transcription factor Nrf2 on Parkinson’s disease. The most important requirement is that the experimenter fully understands the reasons for undertaking this particular self-experimentation and medical risks involved in ingesting sulforaphane. This requirement is essential to enable the experimenter to make an informed personal decision to proceed or not and to reduce the risks of accidents to a strict minimum. The success of this program requires that all participants are fully committed to completing the experimental program (low dropout rate). People who demonstrate their willingness to achieve the required level of understanding and commitment will be contacted to discuss the possibility of their participation in a future self-experimentation program.

  1. Experimenters must understand the different processes involved in making the tea and why we use a two-step protocol to make sulforaphane.
  2. Experimenters must learn how sulforaphane interacts with cells in the body to upregulate Nrf2, what happens when Nrf2 is activated and how long we believe the effects last. They should know what we hope to achieve by using sulforaphane to treat specific symptoms of Parkinson’s disease. They should also know which symptoms are likely be affected over the timescale of the experiment and which are unlikely to be affected.
  3. This level of understanding is necessary for an experimenter to be able to take an informed personal decision about the risks involved and to be able to discuss the matter with his medical professional. Taking BST is a personal decision. It is for the experimenter, after having discussed the matter with his doctor, to decide for himself whether he has the required level of understanding to make that informed decision. 
Q: Why should i become a BS-RG member if I don’t intend or don’t expect to participate in the self-experimentation?

The main reason to join the BS-RG is to support the research program of the Group. This research program is unique in that it is designed and run by People with Parkinson’s disease to investigate the effects of BST on individual symptoms that severely impact the Quality of Life of those affected. It’s principal objective is to develop a method to slow or stop the progression of Parkinson’s disease and ultimately make it available to all Parkinson’s disease sufferers. In the short term, priority of any new information obtained from this research will be given to BS-RG members.

The BS-RG program will only be scientifically viable if the whole program is supported by its members and receives adequate funding.

To join the BS-RG, please activate the inscription form here:

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4 thoughts on “The Broccoli & Sulforaphane Research Group for Parkinson’s Disease”

    1. Impressive article! Well written and very easy to understand by lay persons. Understanding that standardized BST could use the NRF2 pathway to block free radical damage at the mitochondria level is an important key .

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  1. Other patient Scientists Ben Stecher (Ontario), Gary Sharpe PhD(UK) and Frank Church PhD would be terrific subject/assets for this project. They are widely known and published at various levels. Ben and Frank are DBS. Not sure about Gary.

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  2. Hi just stumbled on this page by pure chance but comprehending the cause of mental disease and other degenerative/autoimmune diseases and most importantly how to fix them, is a subject that i am very de interested on . After reading on the strategy that (STOP) are implementing to deal with the damage to the dopaminergic neurons i would like share a few ideas, and also to bring to your attention that it is possible to also use Moringa plant to activate NRF2 just as strongly as sulforaphane from broccoli seeds https://link.springer.com/article/10.1208/s12248-019-0301-6
    Also since the reason you pursuing NRF2 gene activation is to block the free radical damage at the level of the mitochondria why not use the main antioxidant the mitochondria already produces and uses to fight the oxidative damage ? Melatonin is the most powerful endogenous antioxidant that can block mitochondrial damage in a very effective way once it reacts with a oxygen species the metabolites it produces can further continue to fight free radicals without needing to be recycled this way not depleting other antioxidant stores , it also can repair the mitochondrial dysfunction and reestablish normal energy 36/38 ATP’s production by stopping the vicious cycle ((Warburg effect 4 ATP’s ) i think that due the nature of the molecule Melatonin it can achieve the same as NRF2 activation https://encyclopedia.pub/entry/25874 and both strategy’s should complement each other very well. High dose melatonin is very safe almost side effect free (it has been already used for the same reasons to treat PD patients )
    Another thing i would like to add is stopping the damage and protecting the Neurons is extremely important and will probably stop progression of the disease , but that is not enough we must also understand the root cause so we can fix it, there has been some amazing research done on the field of the microbiome with some very astonishing results linking the onset of Parkinson with a dysfunctional microbiome (most people with Parkinson disease have usually had gut problems , leaky gut , constipation etc) when doing Fecal mater transplant using a PD patient as a donor to implant their microbiome on mice grown on completely sterile conditions (no microbiome) , the mice develop Parkinson disease symptoms showing that the microbe profile of the gut can be a strong causative factor , the same have been done with other degenerative diseases with similar outcomes , also cases of Alzheimer ,dementia and bipolar disorder have seen improvements or total remission after receiving FMT from healthy donors .
    One therapy that have been showing amazing results on the treatment of Parkinson disease is Fetal stem cells injections where patients have regained the control of their motor skills , unfortunately it has been blocked from being implemented on most of the world and it is just available in Ukraine from Emcell clinic , this is nice documentary that shows the success it as in various diseases (including Parkinson) https://www.youtube.com/watch?v=Gw7fkz80380

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