The Broccoli & Sulforaphane Research Group for Parkinson’s Disease

Page 2: Contents

Page 2: The science behind BS-RG

Part of the program of the BS-RG concerns self-experimentation with a broccoli seed tea containing sulforaphane. Engaging in self-experimentation is a personal decision that requires the experimenter to know exactly what he or she is doing and to fully understand all the steps involved. Consequently, potential participants are advised to read and digest all the articles on the https://patientresearcher.com/ website and to validate the information given by reading other sources. They should also participate in our regular zoom meetings to become fully informed about the project through discussions with others. The following texts are an introduction to the science behind the BS-RG.

Oxidative stress and the transcription factor Nrf2

The scientific arguments for using broccoli seed tea to slow or stop Parkinson’s disease are explained in the very first post that I wrote for this website, entitled: Resetting the Redox Balance to fight Parkinson’s Disease. If you are new to this site, then this is the first post you should read. This article describes the one of cellular processes that normally protect cells from oxidative stress, but which decline with age.

Wait a minute, what is oxidative stress ?

Oxidative Stress (OS) occurs inside cells, including neurons. Mitochondria make energy from glucose and this process usually produces small quantities of oxidizing chemicals (called Reactive Oxygen Species or ROS) which attack and damage membranes and lipids in cells. In severe cases, the cells can die from too much oxidative stress. There are built-in mechanisms to neutralize these oxidizing chemicals. The most important one is called the Nrf2/ARE pathway which normally detects and recognizes excessive amounts of ROS and responds to the threat by expressing enzymes and other chemicals to neutralize them.

The Nrf2/ARE pathway? That sounds complicated

Yes it is, but this is all explained in plain language in the article entitled : Resetting the Redox Balance to fight Parkinson’s Disease which you can find on this site. If you are new to this site, then this is the first article you should read. It describes the one of the most important cellular processes that protect cells from oxidative stress. These processes decline with age but we can reactivate them using sulforaphane. Preventing oxidative stress and its effects on mitochondria in neurons that make dopamine is our strategy to fight Parkinson’s disease.

safety issues related to activating NRF2.

Sulforaphane is a bioactive substance that can affect your health. There is considerable evidence that people with Parkinson’s disease will benefit by reducing oxidative stress and protecting neurons from damage. In certain cases, doctors may advise against activating Nrf2. These arguments have to be weighed against the fact that doing nothing is not neutral but means accepting Parkinson’s disease progression.

Nrf2 is not only active in the brain, but also in many other tissues which have a high energy consumption such as the heart muscles, urinary tract, liver, digestive system, skin, retina etc. Any activation of Nrf2 will automatically increase expression of Nrf2 targeted genes in these organs. These are on-target effects of upregulating Nrf2. You should also know about the so-called double-edged sword of Nrf2 in relation to cancer. Upregulating Nrf2 by sulforaphane is known to be very strongly protective against many forms of cellular dysfunction including genetic mutations that can lead to cancer. However, some types of cancer cells upregulate Nrf2 to protect the cancer cells from attack, including the action of anti-cancer medication. In this case activating Nrf2 will prevent anti-cancer medication from doing its job. For all these reasons, you need to know enough about these issues to be able to discuss them with your medical professional before starting any treatment based on sulforaphane.

Standardization and Self-experimentation

Taking measures towards standardization of the source seeds and the processing protocol, are necessary steps towards designing a good experimental program to enable BS-RG members with Parkinson’s to evaluate the effects of the broccoli seed tea through self-experimentation.

The individual data collected from the self-experimentation will remain fully confidential, but reports on the collective results, after statistical analysis will be made available to all active BS-RG members as soon as possible after each program. We do not have the means and it is not desirable that all BS-RG members participate in self-experimentation. Each test and each tester carries a finite risk of adverse events and these risks must be kept to a strict minimum. The overall objective is that all members who contribute to the group effort can benefit from the results of this research.  

Membership of the BS-RG

The BS-RG is currently reorganizing its activities on several fronts in preparation for considerable expansion of its activities. This reorganization began in September 2022 and will continue for some months. The scope of the activities of the Group and the way these activities will be organized and managed are all being reviewed. The main points are listed below.

  1. An 8-member Management Team has been established to oversee the reorganization, the activities and the funding of the Group.
  2. The BS-RG has created 2 distinct activity spaces, each with its own mode of operation and objectives.

The Facebook Group of the BS-RG is a discussion group, freely open to anyone with an interest in Parkinson’s disease to discover broccoli seeds and sulforaphane in the context of neurodegenerative diseases. Its purpose is to enable its members to post and discuss articles, publications or documents related to broccoli, sulforaphane and Parkinson’s disease and learn more about this subject without being a member of the Experimental Arm. The Facebook page can be found here:
https://www.facebook.com/groups/645876747094585

The Experimental Arm of the BS-RG is dedicated to practical research on the preparation and applications of Broccoli Seed Tea. It brings together people committed to participating in, organizing or promoting experimental research with sulforaphane with the aim of slowing the progression of Parkinson’s disease. It also supports research into the science of broccoli seeds, sprouts, the preparation of sulforaphane and other bio-active isothiocyanates from broccoli seeds or other plant sources. This section also welcomes people without Parkinson’s disease who wish to learn more about our activities with the aim of promoting our work or bringing in additional competencies.

To join the Experimental arm of the BST-RG, please click on inscription form button here:

  1. The BST testing program of the Experimental arm is organized into groups associated with specific Parkinson’s disease symptoms. Each group will operate under the guidance of a Symptom Group Manager, where possible seconded by another member. The Symptom Group structure enables the method(s) of symptom monitoring and reporting to be adapted to the dominant symptom of the group’s participants. Participants may belong to symptom groups of their choice. At the present time, 3 Symptom Groups are being set up: Urinary Urgency (UU), Chronic Fatigue (CF) and Speech Impairment (SI). Others will be added as resources permit.
  2. Members of the Experimental Arm who wish to take part in self-experimentation with BST are expected to become fully acquainted with the basic science of the causes of Parkinson’s disease, how sulforaphane can help slow disease progression and the science and techniques involved in making BST.
  3. To facilitate the integration of new members, the group is planning to create Zoom sessions to enable them to learn more about this project. These sessions will enable all new members to meet and question seasoned members and the management team.
  4. Recent information from research carried out on the kinetics of the conversion of Glucoraphanin to Sulforaphane has led to radical changes in the protocol used for the preparation of the BST.. This information, uniquely available to Experimental BS-RG members, was made possible through novel analytical techniques developed by Dr Wright. Over the coming months, this research will continue in order to refine the techniques and further extend our knowledge of sulforaphane and other isothiocyanates.
  5. We believe that this research will enable the BS-RG to play a leading role in the field of sulforaphane delivery methods for Parkinson’s and other diseases. It has allowed the Group to considerably improve and standardize its version of broccoli seed tea. We are now exploring and testing various options designed to simplify the Protocol whilst ensuring that each option will deliver the same high-quality standardized tea.
    We believe that this research will enable the BS-RG to play a leading role in the field of sulforaphane delivery methods for Parkinson’s and other diseases. It has allowed the Group to considerably improve and standardize its version of broccoli seed tea. We are now exploring and testing various options designed to simplify the Protocol whilst ensuring that each option will deliver the same high-quality standardized tea.
  6. The operations of the BS-RG research and testing programs incur a great deal of organizational, human and material costs. These costs will grow considerably in the coming months and years as the testing program expands. For the past 3 years, this cost burden has been supported personally by Dr Wright.
    As from 1st December 2022 all members of the Experimental arm of the BS-RG will be asked to contribute to these costs through an annual subscription fee and/or donations.
  7. A nominal annual subscription fee of $200 per member, has been identified by the Management Team. This is not a fixed fee. Contributions by members who wish to support the actions of the group by donating an amount greater than the nominal fee will be greatly appreciated. Equally, anyone wishing to contribute a smaller amount can do so without distinction. All payments and donations will remain confidential.  The fees will be collected on a country-by-country basis. Frank Mundo has agreed to take care of membership registration and payment records. Finally, we invite anyone wishing to support the activities of the Group with donations of $1000 or more and they will be acknowledged as “Benefactor Members”. Membership at any level neither requires nor guarantees participation in the active testing program. The decision to participate or not in the testing program is a personal choice by each individual member.

To join the BST-RG, please click on inscription form button here:

6 thoughts on “The Broccoli & Sulforaphane Research Group for Parkinson’s Disease”

    1. Impressive article! Well written and very easy to understand by lay persons. Understanding that standardized BST could use the NRF2 pathway to block free radical damage at the mitochondria level is an important key .

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  1. Other patient Scientists Ben Stecher (Ontario), Gary Sharpe PhD(UK) and Frank Church PhD would be terrific subject/assets for this project. They are widely known and published at various levels. Ben and Frank are DBS. Not sure about Gary.

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  2. Hi just stumbled on this page by pure chance but comprehending the cause of mental disease and other degenerative/autoimmune diseases and most importantly how to fix them, is a subject that i am very de interested on . After reading on the strategy that (STOP) are implementing to deal with the damage to the dopaminergic neurons i would like share a few ideas, and also to bring to your attention that it is possible to also use Moringa plant to activate NRF2 just as strongly as sulforaphane from broccoli seeds https://link.springer.com/article/10.1208/s12248-019-0301-6
    Also since the reason you pursuing NRF2 gene activation is to block the free radical damage at the level of the mitochondria why not use the main antioxidant the mitochondria already produces and uses to fight the oxidative damage ? Melatonin is the most powerful endogenous antioxidant that can block mitochondrial damage in a very effective way once it reacts with a oxygen species the metabolites it produces can further continue to fight free radicals without needing to be recycled this way not depleting other antioxidant stores , it also can repair the mitochondrial dysfunction and reestablish normal energy 36/38 ATP’s production by stopping the vicious cycle ((Warburg effect 4 ATP’s ) i think that due the nature of the molecule Melatonin it can achieve the same as NRF2 activation https://encyclopedia.pub/entry/25874 and both strategy’s should complement each other very well. High dose melatonin is very safe almost side effect free (it has been already used for the same reasons to treat PD patients )
    Another thing i would like to add is stopping the damage and protecting the Neurons is extremely important and will probably stop progression of the disease , but that is not enough we must also understand the root cause so we can fix it, there has been some amazing research done on the field of the microbiome with some very astonishing results linking the onset of Parkinson with a dysfunctional microbiome (most people with Parkinson disease have usually had gut problems , leaky gut , constipation etc) when doing Fecal mater transplant using a PD patient as a donor to implant their microbiome on mice grown on completely sterile conditions (no microbiome) , the mice develop Parkinson disease symptoms showing that the microbe profile of the gut can be a strong causative factor , the same have been done with other degenerative diseases with similar outcomes , also cases of Alzheimer ,dementia and bipolar disorder have seen improvements or total remission after receiving FMT from healthy donors .
    One therapy that have been showing amazing results on the treatment of Parkinson disease is Fetal stem cells injections where patients have regained the control of their motor skills , unfortunately it has been blocked from being implemented on most of the world and it is just available in Ukraine from Emcell clinic , this is nice documentary that shows the success it as in various diseases (including Parkinson) https://www.youtube.com/watch?v=Gw7fkz80380

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    1. Tried to enter my occupation in the skills section of inscription but it won’t allow any entry. Also, there is no USA on the country list.

      Liked by 1 person

      1. Thanks for this info Bob Wood. Sorry about that. There were several errors in the design of that inscription form that went unnoticed. I have corrected it and hopefully it will now work properly.

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