Page 2: Contents
- Page 1: We are People with Parkinson’s Disease ● Standardizing the preparation of high-quality Broccoli Seed Tea ● Attenuating the impact of Parkinson’s Disease on QoL, One Symptom At a Time (OSAT) ● Sulforaphane activates the transcription factor Nrf2, the master regulator of cellular redox balance ● A strategy to stop Parkinson’s Disease: resolving mitochondrial dysfunction in dopaminergic neurons ●
- Page 2: The science behind BS-RG ● How does the BS-RG work?
- Page 3: Frequently asked questions
Page 2: The science behind BS-RG
Part of the program of the BS-RG concerns self-experimentation with a broccoli seed tea containing sulforaphane. Engaging in self-experimentation is a personal decision that requires the experimenter to know exactly what he or she is doing and to fully understand all the steps involved. Consequently, potential participants are advised to read and digest all the articles on the https://patientresearcher.com/ website and to validate the information given by reading other sources. They should also participate in our regular zoom meetings to become fully informed about the project through discussions with others. The following texts are an introduction to the science behind the BS-RG.
Oxidative stress and the transcription factor Nrf2
The scientific arguments for using broccoli seed tea to slow or stop Parkinson’s disease are explained in the very first post that I wrote for this website, entitled: Resetting the Redox Balance to fight Parkinson’s Disease. If you are new to this site, then this is the first post you should read. This article describes the one of cellular processes that normally protect cells from oxidative stress, but which decline with age.
Wait a minute, what is oxidative stress ?
Oxidative Stress (OS) occurs inside cells, including neurons. Mitochondria make energy from glucose and this process usually produces small quantities of oxidizing chemicals (called Reactive Oxygen Species or ROS) which attack and damage membranes and lipids in cells. In severe cases, the cells can die from too much oxidative stress. There are built-in mechanisms to neutralize these oxidizing chemicals. The most important one is called the Nrf2/ARE pathway which normally detects and recognizes excessive amounts of ROS and responds to the threat by expressing enzymes and other chemicals to neutralize them.
The Nrf2/ARE pathway? That sounds complicated
Yes it is, but this is all explained in plain language in the article entitled : Resetting the Redox Balance to fight Parkinson’s Disease which you can find on this site. If you are new to this site, then this is the first article you should read. It describes the one of the most important cellular processes that protect cells from oxidative stress. These processes decline with age but we can reactivate them using sulforaphane. Preventing oxidative stress and its effects on mitochondria in neurons that make dopamine is our strategy to fight Parkinson’s disease.
safety issues related to activating NRF2.
Sulforaphane is a bioactive substance that can affect your health. There is considerable evidence that people with Parkinson’s disease will benefit by reducing oxidative stress and protecting neurons from damage. In certain cases, doctors may advise against activating Nrf2. These arguments have to be weighed against the fact that doing nothing is not neutral but means accepting Parkinson’s disease progression.
Nrf2 is not only active in the brain, but also in many other tissues which have a high energy consumption such as the heart muscles, urinary tract, liver, digestive system, skin, retina etc. Any activation of Nrf2 will automatically increase expression of Nrf2 targeted genes in these organs. These are on-target effects of upregulating Nrf2. You should also know about the so-called double-edged sword of Nrf2 in relation to cancer. Upregulating Nrf2 by sulforaphane is known to be very strongly protective against many forms of cellular dysfunction including genetic mutations that can lead to cancer. However, some types of cancer cells upregulate Nrf2 to protect the cancer cells from attack, including the action of anti-cancer medication. In this case activating Nrf2 will prevent anti-cancer medication from doing its job. For all these reasons, you need to know enough about these issues to be able to discuss them with your medical professional before starting any treatment based on sulforaphane.
Standardization and Self-experimentation
Taking measures towards standardization of the source seeds and the processing protocol, are necessary steps towards designing a good experimental program to enable BS-RG members with Parkinson’s to evaluate the effects of the broccoli seed tea through self-experimentation.
The individual data collected from the self-experimentation will remain fully confidential, but reports on the collective results, after statistical analysis will be made available to all active BS-RG members as soon as possible after each program. We do not have the means and it is not desirable that all BS-RG members participate in self-experimentation. Each test and each tester carries a finite risk of adverse events and these risks must be kept to a strict minimum. The overall objective is that all members who contribute to the group effort can benefit from the results of this research.
How does the BS-RG work?
Membership and fees
The BS-RG is currently an informal group and membership is free of charge. However, the development of the group’s activities going forward will depend on adequate funding to cover future administrative, experimental and development costs. The BS-RG is a way for People with Parkinson’s to contribute collectively to a serious research effort to fight Parkinson’s disease, run by People with Parkinson’s for People with Parkinson’s using an inexpensive plant-based solution.
To get the best out of the BS-RG, you should take the time to try to understand how sulforaphane interacts with the Nrf2/ARE pathway to stimulate genes to fight the causes of Parkinson’s disease progression. It’s all here in one place on this website. Some of the the articles listed under “Documents” are detailed scientific articles that you may find difficult to understand at first, but with time and effort, you will gradually get to grasp the sense of what we are trying to do. We are also here to explain all that. The bottom line is that the science strongly indicates that sulforaphane in BST should stop or at least slow Parkinson’s disease progression.
Advantages of membership of the Broccoli & Sulforaphane Research Group
The BS-RG aims to offer its members several privileges in the form of new information or analysis not available to the general public.
In addition to the website, we are planning to publish a Confidential BS-RG Newsletter which members will be able to subscribe to for a modest fee. The newsletter will be used as a vehicle to provide members with the most up to date information of the following nature:
- Information on Parkinson’s disease research from some of the world’s leading scientists, reviewed and written in plain language by Dr Albert Wright, a research scientist with Parkinson’s disease.
- Specific information on how sulforaphane interacts with the Nrf2 transcription factor to fight the processes driving Parkinson’s disease progression, especially oxidative stress and mitochondrial dysfunction.
- Reports of self-experimentation by BS-RG members to determine how sulforaphane affects Parkinson’s disease symptoms.
- Reports of laboratory testing to determine the suitability of commercially available broccoli seeds to make BST.
- Reports on experimental results designed to establish a standardized protocol to reliably make broccoli seed tea.
- Reports on sourcing broccoli seeds for members’ personal use beyond the planned experimental program of the Group.
As with any collective organisation, members have rights but also obligations.
- BS-RG members must not divulge confidential information to non-members,
- BS-RG members will be asked to contribute to the future running costs of the group when the decision is made to establish an official body (possibly non-profit society).
To join the BST-RG, please click on inscription form button here: